Stanley I Rapoport Selected Research

Coenzyme A Ligases (Acid-Thiol Ligases)

12/2014	Valnoctamide, a non-teratogenic amide derivative of valproic acid, inhibits arachidonic acid activation in vitro by recombinant acyl-CoA synthetase-4.
4/2013	Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorder.
3/2011	Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder.
12/2008	Arachidonic acid and the brain.

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Stanley I Rapoport Research Topics

Disease

51	Bipolar Disorder (Manic Depressive Psychosis) 04/2021 - 07/2002
28	Neuroinflammatory Diseases 01/2022 - 01/2003
17	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 05/2002
16	Mania (Manias) 01/2020 - 07/2002
6	Dementia (Dementias) 01/2022 - 02/2002
4	Inflammation (Inflammations) 01/2022 - 01/2011
4	Brain Diseases (Brain Disorder) 11/2018 - 08/2007
4	Schizophrenia (Dementia Praecox) 01/2015 - 08/2012
4	Parkinson Disease (Parkinson's Disease) 08/2014 - 06/2005
4	Cognitive Dysfunction 10/2012 - 11/2005
4	Down Syndrome (Down's Syndrome) 01/2006 - 09/2002
3	Infections 01/2021 - 02/2011
3	Mood Disorders (Mood Disorder) 01/2014 - 01/2007
3	Atrophy 01/2013 - 03/2004
3	Ischemia 09/2008 - 12/2002
2	Major Depressive Disorder (Major Depressive Disorders) 10/2016 - 11/2007
2	Pain (Aches) 01/2016 - 04/2015
2	Neurocognitive Disorders (Clerambault Syndrome) 05/2015 - 09/2012
2	Insulin Resistance 10/2012 - 01/2011
2	Dystonia (Limb Dystonia) 09/2012 - 11/2010
2	Parkinsonian Disorders (Parkinsonism) 09/2012 - 11/2010
2	Brain Ischemia (Cerebral Ischemia) 09/2008 - 12/2002
2	Decapitation 09/2008 - 05/2005
1	Hypertension (High Blood Pressure) 01/2021
1	Coinfection 01/2021
1	Overweight 01/2018
1	Cyclothymic Disorder 10/2016
1	Mitochondrial Diseases (Mitochondrial Disease) 05/2016
1	Chronic Pain 01/2016

Drug/Important Bio-Agent (IBA)

49	Arachidonic Acid (Vitamin F)IBA 04/2021 - 07/2002
26	LithiumIBA 01/2020 - 07/2002
18	Phospholipids (Phosphatides)FDA LinkGeneric 12/2014 - 01/2003
13	Valproic Acid (Depakote)FDA LinkGeneric 01/2017 - 07/2002
12	Carbamazepine (Tegretol)FDA LinkGeneric 06/2009 - 07/2002
10	LipopolysaccharidesIBA 01/2017 - 03/2004
10	EnzymesIBA 05/2015 - 07/2002
9	Fatty Acids (Saturated Fatty Acids)IBA 11/2018 - 03/2004
9	LipidsIBA 01/2016 - 06/2005
8	N-Methylaspartate (NMDA)IBA 05/2016 - 09/2007
8	Proteins (Proteins, Gene)FDA Link 01/2015 - 07/2002
7	CalciumIBA 01/2022 - 01/2006
7	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 11/2018 - 11/2007
7	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2018 - 01/2006
7	Biomarkers (Surrogate Marker)IBA 10/2016 - 02/2002
7	Docosahexaenoic AcidsIBA 01/2013 - 01/2003
7	Phospholipases (Phospholipase)IBA 02/2010 - 01/2003
6	Pharmaceutical PreparationsIBA 01/2022 - 02/2002
6	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 04/2021 - 01/2010
6	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2020 - 07/2005
5	Apolipoprotein E4IBA 01/2022 - 01/2011
5	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 08/2012 - 08/2006
5	Lamotrigine (Lamictal)FDA LinkGeneric 08/2012 - 09/2007
5	Glucose (Dextrose)FDA LinkGeneric 12/2011 - 05/2002
4	Phospholipases A2 (Phospholipase A2)IBA 01/2022 - 03/2004
4	Linoleic Acid (Linoleate)IBA 11/2018 - 04/2015
4	EicosanoidsIBA 01/2018 - 09/2008
4	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2015 - 03/2009
4	Coenzyme A Ligases (Acid-Thiol Ligases)IBA 12/2014 - 12/2008
3	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2020 - 07/2002
3	Dopamine (Intropin)FDA LinkGeneric 08/2014 - 10/2007
3	Messenger RNA (mRNA)IBA 10/2012 - 01/2003
3	Calcium-Independent Phospholipases A2IBA 09/2012 - 09/2008
3	Serotonin (5 Hydroxytryptamine)IBA 02/2012 - 01/2007
3	Cholinergic Agents (Cholinergics)IBA 02/2012 - 09/2002
3	tau Proteins (tau Protein)IBA 12/2011 - 08/2002
3	Amyloid (Amyloid Fibrils)IBA 01/2011 - 10/2003
3	Transcription Factors (Transcription Factor)IBA 06/2009 - 08/2007
2	Apolipoproteins E (ApoE)IBA 01/2022 - 01/2021
2	Celecoxib (Celebrex)FDA Link 04/2021 - 01/2020
2	8-epi-prostaglandin F2alphaIBA 05/2016 - 05/2015
2	Dinoprostone (PGE2)FDA Link 05/2015 - 11/2007
2	Antidepressive Agents (Antidepressants)IBA 06/2014 - 10/2009
2	Fluoxetine (Prozac)FDA LinkGeneric 06/2014 - 01/2007
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2014 - 06/2009
2	Antipsychotic Agents (Antipsychotics)IBA 08/2012 - 10/2011
2	AcetylcholinesteraseIBA 02/2012 - 01/2009
2	NF-kappa B (NF-kB)IBA 06/2009 - 08/2007
2	Antimanic AgentsIBA 11/2007 - 07/2002
2	12- (4'- azido- 2'- nitrophenoxy)dodecanoyl- coenzyme AIBA 03/2006 - 12/2002
2	Acyl Coenzyme A (Acyl CoA)IBA 01/2006 - 11/2005
2	Topiramate (Topamax)FDA LinkGeneric 07/2005 - 05/2005
2	Anticonvulsants (Antiepileptic Drugs)IBA 07/2005 - 07/2002
2	Threonine (L-Threonine)FDA Link 02/2003 - 08/2002
1	p38 Mitogen-Activated Protein KinasesIBA 01/2022
1	Leukotriene B4IBA 01/2022
1	Apolipoprotein E3IBA 01/2022
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021
1	ApolipoproteinsIBA 03/2017
1	valnoctamideIBA 01/2017
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2017
1	Essential Fatty AcidsIBA 10/2016
1	Glutamic Acid (Glutamate)FDA Link 05/2016
1	Neuroprotective AgentsIBA 05/2016
1	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 05/2016
1	AutacoidsIBA 01/2016
1	Eicosapentaenoic AcidIBA 11/2015
1	lipoxin A4IBA 05/2015

Therapy/Procedure

4	Intraventricular Infusions 05/2012 - 08/2007
2	Therapeutics 01/2021 - 08/2014
1	Drug Therapy (Chemotherapy) 10/2016